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Characterization of subcellular localization of eukaryotic clamp loader/unloader and its regulatory mechanism.
Park SH, Kim SJ, Myung K, Lee KY. Park SH, et al. Sci Rep. 2021 Nov 8;11(1):21817. doi: 10.1038/s41598-021-01336-w. Sci Rep. 2021. PMID: 34751190 Free PMC article.
The enzymatic activities of PCNA loading and unloading have been studied extensively in vitro. However, the subcellular locations of PCNA loaders, replication complex C (RFC) and CTF18-RFC-like-complex (RLC), and PCNA unloader ATAD5-RLC remain elusive, and the role of thei …
The enzymatic activities of PCNA loading and unloading have been studied extensively in vitro. However, the subcellular locations of PCNA …
The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts.
Cooper DL, Harada T, Tamazi S, Ferrazzoli AE, Lovett ST. Cooper DL, et al. mBio. 2021 Mar 9;12(2):e00184-21. doi: 10.1128/mBio.00184-21. mBio. 2021. PMID: 33688004 Free PMC article.
This complex includes the polymerase and proofreading subunits, the processivity clamp, and clamp loader complex. The holC gene encodes an accessory protein (known as chi) to the core clamp loader complex and is the only protein of the holoenzyme that binds to singl …
This complex includes the polymerase and proofreading subunits, the processivity clamp, and clamp loader complex. The holC gene encod …
Review: The lord of the rings: Structure and mechanism of the sliding clamp loader.
Kelch BA. Kelch BA. Biopolymers. 2016 Aug;105(8):532-46. doi: 10.1002/bip.22827. Biopolymers. 2016. PMID: 26918303 Review.
Sliding clamps are ring-shaped polymerase processivity factors that act as master regulators of cellular replication by coordinating multiple functions on DNA to ensure faithful transmission of genetic and epigenetic information. Dedicated AAA+ ATPase machines called clamp loa
Sliding clamps are ring-shaped polymerase processivity factors that act as master regulators of cellular replication by coordinating multipl …
Evolution of replication machines.
Yao NY, O'Donnell ME. Yao NY, et al. Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):135-49. doi: 10.3109/10409238.2015.1125845. Epub 2015 Dec 20. Crit Rev Biochem Mol Biol. 2016. PMID: 27160337 Free PMC article. Review.
The machines that decode and regulate genetic information require the translation, transcription and replication pathways essential to all living cells. Thus, it might be expected that all cells share the same basic machinery for these pathways that were inherited from the …
The machines that decode and regulate genetic information require the translation, transcription and replication pathways essential to all l …
Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination.
Park SH, Kim N, Kang N, Ryu E, Lee EA, Ra JS, Gartner A, Kang S, Myung K, Lee KY. Park SH, et al. Nucleic Acids Res. 2023 Oct 27;51(19):10519-10535. doi: 10.1093/nar/gkad776. Nucleic Acids Res. 2023. PMID: 37739427 Free PMC article.
Rapid PCNA loading onto DNA at DSB sites depends on the RFC PCNA loader complex and MRE11-RAD50-NBS1 nuclease complexes bound to CtIP. ...
Rapid PCNA loading onto DNA at DSB sites depends on the RFC PCNA loader complex and MRE11-RAD50-NBS1 nuclease complexes bound to CtIP …
Three-Dimensional hybrid structure loader type flexible supercapacitor based on Polyvinyl alcohol gel and Acetylene black.
Wu Z, Guo C, Dai J, Lu Z, Yuan C, Zeng B, Xu Y, Dai L. Wu Z, et al. J Colloid Interface Sci. 2022 Jun 15;616:268-278. doi: 10.1016/j.jcis.2021.12.155. Epub 2022 Jan 3. J Colloid Interface Sci. 2022. PMID: 35219192
In our design, the acetylene black and active material are enriched in the polyvinyl alcohol matrix, and the three-dimensional conductive network that can load different active material is formed. The active material can be selected on demand. The basic electrode (also a …
In our design, the acetylene black and active material are enriched in the polyvinyl alcohol matrix, and the three-dimensional conductive ne …
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (psi) and repair protein YoaA.
Sutera VA, Weeks SJ, Dudenhausen EE, Baggett HBR, Shaw MC, Brand KA, Glass DJ, Bloom LB, Lovett ST. Sutera VA, et al. DNA Repair (Amst). 2021 Apr;100:103006. doi: 10.1016/j.dnarep.2020.103006. Epub 2021 Feb 2. DNA Repair (Amst). 2021. PMID: 33582602 Free PMC article.
In Escherichia coli, the replisome consists of the DNA polymerase III holoenzyme, including DNA polymerase, proofreading exonuclease, processivity clamp and clamp loader, as well as a fork helicase, DnaB and primase, DnaG. We provide evidence here that one component of the …
In Escherichia coli, the replisome consists of the DNA polymerase III holoenzyme, including DNA polymerase, proofreading exonuclease, proces …
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country.
Boekstegers F, Scherer D, Barahona Ponce C, Marcelain K, Gárate-Calderón V, Waldenberger M, Morales E, Rojas A, Munoz C, Retamales J, de Toro G, Barajas O, Rivera MT, Cortés A, Loader D, Saavedra J, Gutiérrez L, Ortega A, Bertrán ME, Bartolotti L, Gabler F, Campos M, Alvarado J, Moisán F, Spencer L, Nervi B, Carvajal-Hausdorf D, Losada H, Almau M, Fernández P, Olloquequi J, Fuentes-Guajardo M, Gonzalez-Jose R, Bortolini MC, Acuña-Alonzo V, Gallo C, Linares AR, Rothhammer F, Lorenzo Bermejo J. Boekstegers F, et al. Int J Cancer. 2023 Sep 15;153(6):1151-1161. doi: 10.1002/ijc.34607. Epub 2023 Jun 1. Int J Cancer. 2023. PMID: 37260300
Airway smooth muscle.
Stephens NL. Stephens NL. Lung. 2001;179(6):333-73. doi: 10.1007/s004080000073. Lung. 2001. PMID: 12040426 Review.
Many of the biophysical and biochemical properties of this muscle have been reviewed before (Stephens, 1970; Stephens, 1977; Mulvaney, 1979; Souhrada and Loader, 1979; Stephens and Kroeger, 1980). They resemble those of striated muscle; however, even though mechanical prop …
Many of the biophysical and biochemical properties of this muscle have been reviewed before (Stephens, 1970; Stephens, 1977; Mulvaney, 1979; …
Modeling and Verification of an Acquisition Strategy for Wheel Loader's Working Trajectories and Resistance.
Wang S, Yin Y, Wu Y, Hou L. Wang S, et al. Sensors (Basel). 2022 Aug 11;22(16):5993. doi: 10.3390/s22165993. Sensors (Basel). 2022. PMID: 36015754 Free PMC article.
Considering the complex working conditions of the wheel loader, it is difficult to obtain accurate working resistance, and the actual working resistance is also a relative value. Therefore, a strong correlation between the two curves indicates that the acquisition strategy …
Considering the complex working conditions of the wheel loader, it is difficult to obtain accurate working resistance, and the actual …
47 results